pone.0293640.s006.pdf (513.45 kB)
Evaluation of confidence intervals under distributional misspecification through coverage proportion and width of CI.
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posted on 2023-11-02, 17:37 authored by Tanja Bülow, Ralf-Dieter Hilgers, Nicole HeussenCorresponding Figures for the confidence interval asessment under distributional misspecification for normal and Poisson distribution for a sample size of N = 100 and two LLOQs.
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widely usable toolsimple imputation methodmultiple lower limitslloq ), estimationcensored sample methodci &# 8217bootstrap ci surpassedbootstrap ci ledconfidence interval comparisoncensored sample estimatepoisson distribution affectedmaximum likelihood estimatespoisson distributed datanarrower interval widthlocation parameter meanderived analytical expressionsunquantifiable observations duehigher coverage proportionsinterval widthunquantifiable observationspoint estimatehigh proportionsasymptotic ciwidth sufferedunderlying distributionpoint estimatesestimates appeardistribution parametersxlink ">suitable givessimulation studyresults differedinvestigated choicehigher biasdistributional assumptionscoverage proportion
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