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Estimated population parameter values from fitting the innate immune model with reduced viral production (Eq 2) to viral load data from all animals using a non-linear mixed effects model.

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posted on 2021-01-20, 18:31 authored by Katharine Best, Dan H. Barouch, Jeremie Guedj, Ruy M. Ribeiro, Alan S. Perelson

Relative standard errors are shown in parentheses. Explicit covariate relationships between inoculum dose and initial viral load V0 and between inoculum dose and delay to immune response τ are included, and the median population values of these parameters at each dose are shown in italics. Fixed parameters used in the model fit are: k = 8 d-1, c = 10 d-1, s = 1 d-1, α = 2 d-1, T(0) = 105 ml-1, each with no variability.

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