Enrichment of ATACseq peaks for ChIPseq validated transcription factor binding sites.

Jefferys, Stuart R.; Burgos, Samuel D.; Peterson, Jackson J.; Selitsky, Sara R.; Turner, Anne-Marie W.; James, Lindsey I.; Tsai, Yi-Hsuan; Coffey, Alisha R.; Margolis, David M.; Parker, Joel; Browne, Edward P.

doi:10.1371/journal.ppat.1009346.s014

ppat.1009346.s014.docx (16.86 kB)

Enrichment of ATACseq peaks for ChIPseq validated transcription factor binding sites.

journal contribution

posted on 2021-02-26, 18:42 authored by Stuart R. Jefferys, Samuel D. Burgos, Jackson J. Peterson, Sara R. Selitsky, Anne-Marie W. Turner, Lindsey I. James, Yi-Hsuan Tsai, Alisha R. Coffey, David M. Margolis, Joel Parker, Edward P. Browne

Change in the mean of the ChIPseq TF score for significantly more accessible peaks (FC > 1.5 and FDR < 0.1, sig) vs non-significantly different (unchanged) peaks (FDR > 0.2 and any FC, nonSig). Calculated using Welch’s Two Sample t-test. Box plots of distributions are shown in S5 Fig. AZD = AZD5582, PROST = prostratin, VOR = vorinostat.

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