posted on 2023-11-03, 15:39authored byYao-Du Zhang, Ming Chen, Yang Li, Bo-Wen Liu, Zhi-Hui Ren, Zheng-Hui Guan
The current investigation presents an innovative palladium-catalyzed
asymmetric carbonylative Heck esterification method. This approach
facilitates the efficient synthesis of various chiral γ-ketoacid
esters by utilizing o-alkenyliodobenzenes and arylboronic
acids as primary substrates. This reaction achieves the creation of
three carbon–carbon bonds, two carbon–oxygen bonds,
and the establishment of a quaternary carbon center within a single
step. The α-chiral γ-ketoacid esters were obtained in
yields ranging from good to high yields, displaying enantiomeric excesses
(ee’s) levels up to 92% under mild reaction conditions.