posted on 2023-11-17, 13:37authored byFang Xie, Jie Zhao, Deyue Ren, Jianming Xue, Jingyi Wang, Qin Zhao, Lu Liu, Xiaodan Liu
A Cu-catalyzed
coupling of cyclic imino esters with 2H-azirines
has been developed to synthesize novel optically active
aziridines in high yields with excellent levels of diastereo- and
enantioselectivities under mild conditions. This novel protocol features
a broad substrate scope and good functional group compatibility, and
it enriches the existing reaction type of rapid synthesis of optically
active aziridines bearing vicinal tetrasubstituted stereogenic carbon
centers.