posted on 2023-12-26, 23:31authored byZhang Zhang, Xiu-Jin Meng, Fei-Hu Cui, Hai-Tao Tang, Ying-Chun Wang, Guo-Bao Huang, Ying-Ming Pan
In
this study, a multicomponent reaction via the Mannich
intermediate
was developed using methanol, secondary amine, and sulfonamide as
starting materials. This method uses methanol as a green C1 source.
The substrate scope is wide, and the yield is good. The mechanistic
study shows that methanol generates formaldehyde under electrochemical
conditions, and sulfonyl amidine as a nucleophile reacts with Schiff
base intermediates to form N-sulfonyl amidine in
a single step.