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Efficiency of SCNT in generating ASGR1-deficient pigs.

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posted on 2021-11-11, 18:34 authored by Baocai Xie, Xiaochen Shi, Yan Li, Bo Xia, Jia Zhou, Minjie Du, Xiangyang Xing, Liang Bai, Enqi Liu, Fernando Alvarez, Long Jin, Shaoping Deng, Grant A. Mitchell, Dengke Pan, Mingzhou Li, Jiangwei Wu

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    PLOS Genetics

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    unexpectedly observed mildless atherosclerotic lesionscoa reductase (<moderate hepatic injuryincreases cholesterol clearancediv >< pde novo dependent low levelsdeficient pigs usingpigs show agehumans low levelsdeficient pigshepatic lowvivo ldlr hmgcr hepatic transcriptomecholesterol synthesischolesterol metabolismtogether contributestandard dietreduced riskreduce hypercholesterolemiaeffective strategyclinical evidencecas9 systemcardiovascular similaritiescardiovascular diseasecardioprotective effectatherogenic dietasgr1 6 months

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