pone.0262695.s004.docx (13.26 kB)
Each stroke patient was pair-matched to a control by age and GPVI expression and resting P-selectin exposure was calculated.
journal contribution
posted on 2022-01-18, 18:33 authored by Isuru Induruwa, Harriet McKinney, Carly Kempster, Patrick Thomas, Joana Batista, Jean-Daniel Malcor, Arkadiusz Bonna, Joanne McGee, Elaine Bumanlag-Amis, Karola Rehnstrom, Sophie Ashford, Kenji Soejima, Willem Ouwehand, Richard Farndale, Kate Downes, Elizabeth Warburton, Masaaki Moroi, Stephanie JungThis was done by choosing the first stroke and first control recruited for a specific age. If there was more than one stroke patient for a particular age, the next control recruited of the same age was included. Stroke patients without a corresponding age match were excluded. P-values were calculated using an unpaired t-test for parametric or Mann Whitney-U test for non-parametric data. GPVI-dimer expression (P = 0.003) and resting P-selectin exposure (P <0.0001) remain significantly raised between age-matched stroke and control participants.
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recruited within 8hhealthy control populationincreased stroke severitysmall molecule gpviischemic stroke subtypeshemorrhagic stroke patientsplatelet receptor glycoprotein2 selectin exposure (<active circulating plateletsstroke patientsischemic strokeglycoprotein vicontrol groupstroke expressedcontrols (<p dimer (<whole bloodtotal gpvithrombotic therapythrombotic targetsymptom onsetsurface expressionstudy validateplatelet surfaceplatelet activityplatelet activationflow cytometrydimeric form90 post
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