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Difference in NMD measurement.

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posted on 2021-06-28, 17:22 authored by Ide T. Spaanderman, Fleur S. Peters, Aldo Jongejan, Egbert J. W. Redeker, Cornelis J. A. Punt, Adriaan D. Bins

Density map showing difference between Z-score and VAF-ratio approach for the measurement of Nonsense Mediated Decay (NMD) in NMD RES and SENS mutations. Separation of NMD RES and SENS is clearer with VAF-ratio.

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    Nonsense Mediated DecayColon Cancers71 MSI Colon Cancer patientsMSI ColonSNORF4 Lynch patientsDNA sequencing resultsmutations clustercancer genome atlasimmunotherapy targetsTCGAframeshift peptidesMSI Colon CancerMicrosatellite InstableMSI Colon Cancerscolon cancerTCGA-COADMSI Endometrial20 NMD-escaping Public FPsMMDMSI cancersvariant allele frequencyFrameshift Peptidesimmunotherapeutic strategiesmRNA levelMSI Stomach cancer patientsPFPSuper Neo Open Reading Frame

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