pntd.0011639.s004.docx (848.52 kB)
Development of temperature and weight after direct oral immunization.
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posted on 2024-02-26, 18:42 authored by Magdalena Murr, Conrad Freuling, David Pérez-Bravo, Christian Grund, Thomas C. Mettenleiter, Angela Römer-Oberdörfer, Thomas Müller, Stefan Finke(A) Goats and (B) foxes were directly orally vaccinated with either parental rNDV (n = 3) or RABV G expressing rNDV_GRABV (n = 6). Rectal temperature of goats and foxes as well as weight of foxes was monitored at indicated timepoints after oral vaccination.
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sup >< bstrain clone 30pharyngeal lymph nodesreach spillover speciescarnivore species susceptibleviral rna couldsub >< bvirus neutralizing antibodieswildlife reservoir speciesdirect oral applicationinfectious ndv coulddiv >< psingle oral applicationempty viral vectorthree animals receivedreservoir speciesviral sheddingvaccinated animalssingle dosevirus replicationoral vaccinesoral immunizationtransgene expressiontest immunogenicitysub xmlnssimilar doseseven daysrndv ).representing herbivorenovel potentnasal swabsmammalian cellskey componentimmune responseglobal fightcell activity
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