posted on 2009-12-04, 00:00authored byJianmin Zhang, Elena A. Polishchuk, Jie Chen, Marco A. Ciufolini
The preparation of 4-carbethoxy-5-methyl-2-(phenylsulfonyl)methyloxazole and its use in the elaboration of more complex oxazoles are described. A total synthesis of the unique natural products siphonazoles A and B, illustrates an application of this building block. A discussion of the biological activity of the siphonazoles is also presented.