pone.0257396.s004.docx (14.57 kB)
Details of late-onset and early-onset in three non-montelukast user populations.
journal contribution
posted on 2021-09-22, 17:26 authored by Cyrielle Maroteau, Antonio Espuela-Ortiz, Esther Herrera-Luis, Sundararajan Srinivasan, Fiona Carr, Roger Tavendale, Karen Wilson, Natalia Hernandez-Pacheco, James D. Chalmers, Steve Turner, Somnath Mukhopadhyay, Anke-Hilse Maitland-van der Zee, Esteban G. Burchard, Maria Pino-Yanes, Simon Young, Glenda Lassi, Adam Platt, Colin N. A. Palmer1Exacerbation within 6 months; 2Exacerbation within 12 months; OCS: Oral Corticosteroids; ER: Emergency Room visit; GoSHARE (a) is the late-onset population (>18 years-old); GoSHARE (b) is the early-onset population (< = 18 years-old).
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using logistic regressionprecision medicine approachleast one copyethnically diverse populationsdiv >< p85 %, p62 %, p61 – 404 – 8european ancestry demonstratedregulatory variant rs2660845onset (≤ 18yleast one exacerbationcentral pathophysiological rolesignificant increased riskexperiencing asthma exacerbationsmontelukast treatment experiencingdespite montelukast treatmentci ): 1significant associationasthma exacerbationsmontelukast treatmenttayside rctseven cohortssage ).rs2660845 associationpresumably dueonset subjectsonset asthmamonth periodmay contributelta4h leukotrienes playleukotriene inhibitorsincreased oddgenotyped 3genetic variationgala iifindings supporteuropean lateeuropean individualsethnic groupsconfidence intervalasthma onsetadult asthmaaa group>, together342 ).
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