pgen.1011020.s001.pdf (192.79 kB)
Detailed methods and additional results.
journal contribution
posted on 2023-11-07, 18:34 authored by Joelle Mbatchou, Mark Abney, Mary Sara McPeekDetailed description of the methods, including simulation of genotypes, traits and covariates, incorporating sample structure in the null model, adaptive resampling procedure, and modification of CARAT. Additional results consist of p-values for IE and ED loci from other permutation-based methods.
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type 1 errorphenotype model misspecificationgenetic association analysisdetect significant associationdata adaptive methods6 methods consideredgenetic association studiesmvnpermute method invalidinclude population structuregenetic association testingpopulation structuremvnpermute methodassociation testingassociation mappingassociation analysessimulation studiesbased methodsmodeling structurepermutation methodssimultaneous testingpermutation methodpermutation testingxlink ">wide significancevariance makesvaluable tooltest statisticssuperior controlrare variantsprevious analysesmultiple markersmachine learningie ).idiopathic epilepsyelbow dysplasiadomestic dogcommonly ariseschromosome 35binary traitassessing significanceadmixed individuals
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