DRG filtering in the female rats.

The recordings similar to that shown in Fig 1 but performed in female rats. (A) After baseline was recorded (control), Capsaicin (CAP, 10 μM, 50 μl) was injected into the hindpaw. Application of GABA (200 μM, 3 μl) to DRG reduced CAP-induced firing frequency in DR but not SN (bottom traces). (B) Summary for panel A. Two-factor (nerve site, drug application) repeated measures ANOVA: main effect associated with nerve site [F(1,10) = 8.7; p < 0.05]. Bonferroni post hoc test: *,**significant difference from control (p < 0.05, p < 0.01); ^#significant difference from CAP (p < 0.05). (C) GABA_A antagonist bicuculline (BIC, 200 μM, 3 μl) was applied to DRG; hindpaw was not stimulated. (D) Summary for panel C. Two-factor repeated measures ANOVA: main effects associated with nerve site [F(1,10) = 10.4; p < 0.05], drug application [F(1,10) = 12.2; p < 0.05], significant interaction between nerve site and drug application [F(1,10) = 23.1; p < 0.01]. Bonferroni post hoc test: **significant difference from control (p < 0.01). Metadata for quantifications presented in this figure can be found at https://archive.researchdata.leeds.ac.uk/1042/.

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