posted on 2024-01-16, 13:06authored byYunfei Guo, Jipeng Qi, Hongyu Guo, Rongfang Liu, Rong Zhou
The
construction of a C–C bond by cross-coupling of two
different C–H bonds with the release of hydrogen gas represents
an ideal yet challenging bond formation strategy. Herein, we report
a photocatalytic metal-free cross-coupling of benzylic and aldehydic
C–H bonds by synergistic catalysis of organophotocatalyst 4CzIPN
and a thiol, which affords the corresponding α-aryl ketones
in acceptable yields along with hydrogen evolution. The mechanistic
investigation indicates a radical–radical coupling to give
an intermediary alcohol, followed by an acceptorless alcohol dehydrogenation.