posted on 2022-01-26, 14:45authored byGaochen Xu, Chenglong Jia, Xuemei Wang, Huan Yan, Sai Zhang, Qinghuan Wu, Ning Zhu, Jindian Duan, Kai Guo
The
first example of divergent N-heterocycle syntheses
through a copper-catalyzed three-component reaction of α,β-unsaturated ketoximes, paraformaldehyde,
and amines has been documented. In particular, this divergent synthetic
strategy was achieved by controlling the reaction conditions to afford
the corresponding imidazoles and dihydroimidazoles in moderate to
good yields with a broad substrate scope and good functional group
compatibility.