jo1c01122_si_001.pdf (5.05 MB)
Copper-Catalyzed Cascade Annulation of Malonate-Tethered O‑Acyl Oximes with Cyclic 1,3-Dicarbonyl Compounds for the Synthesis of Spiro-Pentacyclic Derivatives
journal contribution
posted on 2021-08-09, 13:04 authored by Kun Wang, Hong-Rong Guan, Wen-Long Ren, Hai-Tao Yang, Chun-Bao MiaoA copper-catalyzed
cascade annulation of malonate-tethered O-acyl oximes
with cyclic 1,3-dicarbonyl compounds has been
developed for the rapid synthesis of spiro-pentacyclic derivatives.
This reaction allows the one-step formation of five C–C/N/O
bonds and an angular tricyclic core under very mild conditions and
shows excellent regioselectivity and stereoselectivity.
History
Usage metrics
Keywords
Malonate-TetheredDicarbonylSpiro-Pentacyclic DerivativesdicarbonylregioselectivityAcyltricyclic coreCopper-Catalyzed Cascade Annulationspiro-pentacyclic derivativesCompoundSynthesiacyl oximesCyclicmalonate-tethered OformationstereoselectivitycompoundOximecopper-catalyzed cascade annulationsynthesisbond
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC