Construction of
a Biomimetic Receptor Based on Hydrophilic
Multifunctional Monomer Covalent Organic Framework Molecularly Imprinted
Polymers for Molecular Recognition of Cyanidin-3‑O‑Glucoside
posted on 2023-11-08, 22:20authored byQianyu Zhao, Hua Zhang, Haitian Zhao, Hongwei Zhu, Jia Liu, Bin Li, Minjie Li, Xin Yang
Anthocyanins
(AOCs) are phenols that are readily soluble in water
and are commonly present in plants. The chemical instability of AOC,
however, causes it to be severely limited in terms of extraction and
purification. Hence, in order to obtain efficient and stable extraction
of AOC, we designed hydrophilic multifunctional monomer covalent organic
framework molecularly imprinted polymers (HMCMIPs) as adsorbents.
The functional reagent, p-aminobenzenesulfonic acid
(ASA), was added to this material during synthesis to facilitate the
sulfonation modification of covalent organic frameworks (COFs), which
enhanced its affinity for hydrophilic guests (cyanidin-3-O-glucoside, the representative nutritional and functional ingredient
in AOC). With ASA serving as a terminator, overextension of the material
to form micron-level cross-linked structures is prevented, thereby
increasing its surface area and mass transfer efficiency. The biomimetic
receptors were then created by integrating MIPs into sulfonated COFs
in order to create multiple binding sites specific for C3G recognition.
HMCMIPs exhibited excellent adsorption capacity (1566 mg/g) and superior
selectivity (selectivity coefficient >12) for C3G. It has been
demonstrated
that high purity (93.72%) C3G can be obtained rapidly and efficiently
by utilizing HMCMIPs. There may be a potential benefit to the synthesis
strategy of HMCMIPs for the extraction of specific active ingredients
in the future.