Comparison of genome-wide significant independent SNPs discovered in other viral infection phenotypes replicated in the four COVID-19 phenotypes Hospitalized COVID-19 vs. population, COVID-19 vs. self-reported negative, COVID-19 vs. population, predicted COVID-19 from self-reported symptoms vs. predicted or self-reported non-COVID-19.

van Blokland, Irene V.; Lanting, Pauline; Ori, Anil P. S.; Vonk, Judith M.; Warmerdam, Robert C. A.; Herkert, Johanna C.; Boulogne, Floranne; Claringbould, Annique; Lopera-Maya, Esteban A.; Bartels, Meike; Hottenga, Jouke-Jan; Ganna, Andrea; Karjalainen, Juha; Hayward, Caroline; Fawns-Ritchie, Chloe; Campbell, Archie; Porteous, David; Cirulli, Elizabeth T.; Barrett, Kelly M. Schiabor; Riffle, Stephen; Bolze, Alexandre; White, Simon; Tanudjaja, Francisco; Wang, Xueqing; Ramirez, Jimmy M.; Lim, Yan Wei; Lu, James T.; Washington, Nicole L.; de Geus, Eco J. C.; Deelen, Patrick; Boezen, H. Marike; Franke, Lude H.

doi:10.1371/journal.pone.0255402.s002

pone.0255402.s002.pdf (1.5 MB)

Comparison of genome-wide significant independent SNPs discovered in other viral infection phenotypes replicated in the four COVID-19 phenotypes Hospitalized COVID-19 vs. population, COVID-19 vs. self-reported negative, COVID-19 vs. population, predicted COVID-19 from self-reported symptoms vs. predicted or self-reported non-COVID-19.

journal contribution

posted on 2021-08-11, 17:31 authored by Irene V. van Blokland, Pauline Lanting, Anil P. S. Ori, Judith M. Vonk, Robert C. A. Warmerdam, Johanna C. Herkert, Floranne Boulogne, Annique Claringbould, Esteban A. Lopera-Maya, Meike Bartels, Jouke-Jan Hottenga, Andrea Ganna, Juha Karjalainen, Caroline Hayward, Chloe Fawns-Ritchie, Archie Campbell, David Porteous, Elizabeth T. Cirulli, Kelly M. Schiabor Barrett, Stephen Riffle, Alexandre Bolze, Simon White, Francisco Tanudjaja, Xueqing Wang, Jimmy M. Ramirez III, Yan Wei Lim, James T. Lu, Nicole L. Washington, Eco J. C. de Geus, Patrick Deelen, H. Marike Boezen, Lude H. Franke

In each of the 5 GWASs in which we replicated an association in a COVID-19 phenotype Europeans constitute the largest portion of included samples. Three of these contained only European samples. The majority of the samples in the COVID-19 analyses are also of European descent. This suggests that these lead SNPs can be compared, and that replication was not caused by ethnicity differences.

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