pgen.1011037.s004.pdf (92.14 kB)
Comparison of MAF in each cohort with the reference panel CONVERGE.
journal contribution
posted on 2024-01-11, 19:00 authored by Qi-Xin Zhang, Tianzi Liu, Xinxin Guo, Jianxin Zhen, Meng-yuan Yang, Saber Khederzadeh, Fang Zhou, Xiaotong Han, Qiwen Zheng, Peilin Jia, Xiaohu Ding, Mingguang He, Xin Zou, Jia-Kai Liao, Hongxin Zhang, Ji He, Xiaofeng Zhu, Daru Lu, Hongyan Chen, Changqing Zeng, Fan Liu, Hou-Feng Zheng, Siyang Liu, Hai-Ming Xu, Guo-Bo ChenComparison of MAF in CONVERGE with the frequency of the same allele in each cohort. Each hexagonal bin is colored according to the number of markers falling in that bin.
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sharing summary statisticsmany merits comparingimproved statistical powerfinely devised multicommon statistical analysesmasked genotype matriceslevel genotype datarelatives estimated usingencrypted genomic datawidely used softwarevarious degrees basedstudy clearly demonstratesrandom matrix theorycovering 9 cohorts092 gwas samplesencrypted genotype data> b >,div >< pgenotype datarandom matrixb ><> bsearching relativesdetect relativescohort relativesuk biobankstrict qcssearching acrossrespective centersrequired precisionrelative identificationregression approachreg genotypic qualitiesgenomics studiesfalse positiveethical constraintsequivalently accurateencryption propertiescomputationally efficientcomplex application
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