dyz073.pdf (552.6 kB)
Cohort profile: Extended Cohort for E-health, Environment and DNA (EXCEED).
journal contribution
posted on 2019-06-10, 09:19 authored by C John, NF Reeve, RC Free, AT Williams, Ioanna Ntalla, A-E Farmaki, J Bethea, LM Barton, N Shrine, C Batini, R Packer, S Terry, B Hargadon, Q Wang, CA Melbourne, EL Adams, CE Bee, K Harrington, J Miola, NJ Brunskill, CE Brightling, J Barwell, SE Wallace, R Hsu, DJ Shepherd, EJ Hollox, LV Wain, MD Tobin[First paragraph] EXCEED aims to develop understanding of the genetic, environmental and lifestyle-related causes of health and disease. Cohorts like EXCEED, with broad consent to study
multiple phenotypes related to onset and progression of
disease and drug response, have a role to play in medicines
development, by providing genetic evidence that can identify, support or refute putative drug efficacy or identify
possible adverse effects.1 Furthermore, such cohorts are
well suited to the study of multimorbidity.
Funding
The study has been supported by the University of Leicester, the NIHR Leicester Biomedical Research Centre, the NIHR Clinical Research Network East Midlands, Leicester City Council, the Medical Research Council (grant G0902313 to MDT), the Wellcome Trust (grant 202849 to MDT) and a respiratory genomic collaboration with GSK. C.J. holds a Medical Research Council Clinical Research Training Fellowship (MR/P00167X/1). C.B. holds UKRI Innovation Fellowship at Health Data Research UK (MR/S003762/1). L.V.W. holds a GSK/British Lung Foundation Chair in Respiratory Research (grant C17-1).
History
Citation
International Journal of Epidemiology, 2019, dyz073Author affiliation
/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Infection, Immunity and InflammationVersion
- VoR (Version of Record)
Published in
International Journal of EpidemiologyPublisher
Oxford University Press (OUP) for International Epidemiological Association.eissn
1464-3685Acceptance date
2019-03-26Copyright date
2019Available date
2019-06-10Publisher DOI
Publisher version
https://academic.oup.com/ije/advance-article/doi/10.1093/ije/dyz073/5485771Notes
Participants have consented to their pseudonymized data being made available to other approved researchers, and we welcome requests for collaboration and data access. Access to the resource requires completion of a proposal form, including a lay summary of the proposed research. Applications to access the resource will be assessed for consistency with the data access policy and with the guidance of the Scientific Committee, which has participant representation. Access to the data will be subject to completion of an appropriate Data/Materials Transfer Agreement and to necessary funding being in place. Requests to collect new data or to use biological samples may be subject to additional requirements. Interested researchers are encouraged to contact the study management team via exceed@le.ac.uk.;International Journal of Epidemiology, dyz175, https://doi.org/10.1093/ije/dyz175 Published: 31 July 2019 An author of this cohort profile, Ioanna Ntalla, was unintentionally omitted from the author list. Dr Ntalla made a substantial contribution to the design and implementation of the study and meets the criteria for authorship.An author of this cohort profile, Ioanna Ntalla, was unintentionally omitted from the author list. Dr Ntalla made a substantial contribution to the design and implementation of the study and meets the criteria for authorship.Language
enAdministrator link
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