pone.0262293.s002.pdf (80.36 kB)
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posted on 2022-01-24, 18:27 authored by Giorgio Ciminata, Claudia Geue, Olivia Wu, Manuela Deidda, Noemi Kreif, Peter LanghorneICD:10 = International Statistical Classification of Diseases and Related Health Problems 10th Revision, OPCS-4 = Classification of Interventions and Procedures, BNF = British national formulary, VTE = venous thromboembolism.
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unobserved confounding holdprescribing information systeminverse probability weightinghealth technology assessmentexplore methodological challengesdirect oral anticoagulantstreatment effect tendssmaller sample sizesfirst clinical eventpatients &# 8217newly anticoagulated patientsxlink "> overallused linkage databest performing methodassessing covariate balanceps based methodspropensity score methodsxlink ">propensity scoreps methodstreatment switchingsample sizegood balancecovariate adjustmentclinical outcomesworld evidenceversus warfarinusing realstandardised differencemultiple approachesmodel performancemajor bleedingipcw approachincluding apixabancase study2 years
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