posted on 2024-02-23, 21:03authored byZehui Su, Ting Du, Jianxing Feng, Jianlong Wang, Wentao Zhang
Nanozyme has been proven to be an attractive and promising
candidate
to alleviate the current pressing medical problems. However, the unknown
clinical safety and limited function beyond the catalysis of the most
reported nanozymes cannot promise an ideal therapeutic outcome in
further clinical application. Herein, we find that ferric maltol (FM),
a clinically approved iron supplement synthesized through a facile
scalable method, exhibits excellent peroxidase-like activity than
natural horseradish peroxidase-like (HRP) and commonly reported Fe-based
nanozymes, and also shows high antibacterial performance for methicillin-resistant Staphylococcus aureus (MRSA) elimination (100%) and
wound disinfection. In addition, with added effects inherited from
contained maltol, FM can accelerate skin barrier recovery. Therefore,
the exploration of FM as a safe and desired nanozyme provides a timely
alternative to current antibiotic therapy against drug-resistant bacteria.