pone.0293774.s004.docx (3.32 MB)
Clinical trial protocol.
journal contribution
posted on 2023-11-24, 00:26 authored by Juan Carlos Magaña, Cláudia Maria Deus, Laura Baldellou, Merce Avellanet, Elvira Gea-Rodríguez, Silvia Enriquez-Calzada, Ariadna Laguna, Marta Martínez-Vicente, Jorge Hernández-Vara, Maria Giné-Garriga, Susana Patricia Pereira, Joel MontaneClinical trial protocol v4, V4; December 05 2022.
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striatal dopamine deficiencyrelated neuronal losspatients &# 8217pathogenic processes correlatingparkinson &# 8217bptfe ), targetingameliorate neurological impairmentsundergo bpt combinedpatient skin fibroblastsparkex study aimsstage pd patientsskin fibroblaststhree agesurrogate indicatorssensorimotor pathwayssedentary groupsed ).physical activitypd pathogenesisoxidative stressmotor trainingmotor functionmitochondrial functionmitochondrial dysfunctionmitochondrial bioenergeticsmetabolic remodelingmetabolic improvementmatched groupsimpede agegroup 3group 2group 1functional exercisesethical approvalemphasizing strengthconducted preclinical measures12 weeks
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