posted on 2023-01-05, 14:33authored byRomualdo Troisi, Francesco Galardo, Giarita Ferraro, Filomena Sica, Antonello Merlino
The molecular mechanism of how human serum transferrin
(hTF) recognizes
cisplatin at the atomic level is still unclear. Here, we report the
molecular structure of the adduct formed upon the reaction of hTF
with cisplatin. Pt binds the side chain of Met256 (at the N-lobe),
without altering the protein overall conformation.