pone.0257396.s007.docx (24.27 kB)
Cis-eQTL effect of rs2660845 on LTA4H expression in whole blood from adult cohorts.
journal contribution
posted on 2021-09-22, 17:26 authored by Cyrielle Maroteau, Antonio Espuela-Ortiz, Esther Herrera-Luis, Sundararajan Srinivasan, Fiona Carr, Roger Tavendale, Karen Wilson, Natalia Hernandez-Pacheco, James D. Chalmers, Steve Turner, Somnath Mukhopadhyay, Anke-Hilse Maitland-van der Zee, Esteban G. Burchard, Maria Pino-Yanes, Simon Young, Glenda Lassi, Adam Platt, Colin N. A. PalmerBIOSQTL: The Biobank-Based Integrative Omics Study Quantitative Trait Locus; eQTLGen: expression Quantitative Trait Loci Genetic; FDR: False Discovery Rate; ID: Gencode Identifier.
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using logistic regressionprecision medicine approachleast one copyethnically diverse populationsdiv >< p85 %, p62 %, p61 – 404 – 8european ancestry demonstratedregulatory variant rs2660845onset (≤ 18yleast one exacerbationcentral pathophysiological rolesignificant increased riskexperiencing asthma exacerbationsmontelukast treatment experiencingdespite montelukast treatmentci ): 1significant associationasthma exacerbationsmontelukast treatmenttayside rctseven cohortssage ).rs2660845 associationpresumably dueonset subjectsonset asthmamonth periodmay contributelta4h leukotrienes playleukotriene inhibitorsincreased oddgenotyped 3genetic variationgala iifindings supporteuropean lateeuropean individualsethnic groupsconfidence intervalasthma onsetadult asthmaaa group>, together342 ).
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