posted on 2021-09-29, 16:38authored byIrina A. Silanteva, Andrei V. Komolkin, Veronika V. Mamontova, Pavel V. Gabrusenok, Pavel N. Vorontsov-Velyaminov, Svetlana Santer, Nina A. Kasyanenko
The DNA interaction with cis-isomers
of photosensitive azobenzene-containing
surfactants was studied by both experimental methods and computer
simulation. It was shown that before the organization of micelles,
such surfactants in the cis-conformation form associates of only a
single type with a disordered orientation of molecules. In contrast,
for trans-isomers, there exist two types of associates with head-to-head
or head-to-tail orientations of molecules in dependence on salt concentration
in a solution. The comparison of cis- and trans-isomer binding to
DNA and the influence of salt concentration on the formation of their
complexes with DNA were studied. It was shown that cis-isomers interact
with phosphate groups of DNA and that their molecules were also located
along the minor groove of DNA.