pntd.0010046.s001.pdf (168.21 kB)
Chromosomal amplification and deletion in L. tarentolae A150.1.
journal contribution
posted on 2021-12-16, 18:57 authored by Gaétan Roy, Arijit Bhattacharya, Philippe Leprohon, Marc OuelletteLog2-transformed L. tarentolae A150.1/WT gene reads ratios normalized for gene length and total read counts for the 36 chromosomes. Genes along the chromosome are shown as dots on the X axis while the log2-transformed L. tarentolae A150.1/WT reads ratios are indicated by the y axis.
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revealing biochemical pathwaysprominent defect observedgenetic knockout leddiv >< pcontaining gmp synthasechromosome 22 correspondedpotential drug targetsacivicin thus leadingacivicin binds covalentlyshown good activityreduced glutamate transportdecreased glutamate transportmain glutamate transporterleishmania tarentolae decreased transporttarentolae leishmania reduced uptakedrug resistancel acivicin susceptibilityacivicin resistantacivicin resistanceresistant strainresistant mutantprotozoan parasitesmodest roleepisomal expressioneither deletedcompetition experimentsamidotransferase domain
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