posted on 2024-01-23, 17:07authored byKobe Buyse, Evelyne Delezie, Luc Goethals, Noémie Van Noten, Christof Van Poucke, Mathias Devreese, Gunther Antonissen, Geert P. J. Janssens, Marta Lourenço
Studies on the bioavailability,
serum levels, and absorption of
hydrolyzable tannin compounds are lacking. In this study, we performed
a pharmacokinetic trial, measured the serum levels of compounds in
broilers that were reared with different feed added or not with tannins,
and tested the digestibility of tannins throughout the intestinal
tract. Only gallic acid and 4-O-methyl gallic acid
were found in the serum. Moreover, gallic acid showed a 41.8% absolute
oral bioavailability and a 72.3% relative bioavailability of gallic
acid from chestnut extract compared to the standard. The rapid metabolization
caused alternating serum levels during the day and night. These patterns
were not affected by the feed type or the previous addition of tannins
in the feed. The absorption and metabolization in the intestines occurred
gradually throughout the intestinal tract. The latter was true for
gallic acid as well as ellagic acid, which was not found in the serum.
We can conclude that components from chestnut tannins are absorbed
throughout all components of the intestinal tract and are eliminated
quickly with little interaction from the feed and previous addition
of tannins. Moreover, ellagic acid seems to be absorbed but would
remain accumulated in the intestinal tissue or be metabolized by the
microbiome.