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Characterization of lung DC in hACE2 (blue) and hACE2/Batf3KO (red) mice.

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posted on 2023-12-27, 18:31 authored by Liat Bar-On, Hani Dekel, Moshe Aftalion, Theodor Chitlaru, Noam Erez

cDC1 (CD103+CD11b-) and cDC2 (CD103-CD11b+) identification by flow cytometry (A). Quantification of cDC1 and cDC2 in hACE2 and hACE2/Batf3KO mice (B).

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    novel murine linefuture vaccine designdraining lymph nodealso significantly impactedwhereas humoral responses2 susceptible k18xlink "> sarsconsequent impaired cd8batf3 deficient micedependent dendritic cells2 viral load2 specific cd8specific cd8severely impairedregulating cd8dependent dccell responsesspecific role2 infectionsignificant increaseresults underscoreregulating sarsmay contributelargely unknownindependently corroboratedhace2 transgenicessential roleeffector phasecell responsecell immunityadditional covidadapted sars

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