posted on 2021-08-24, 17:37authored byBianca
T. Matsuo, Pedro H. R. Oliveira, José Tiago
M. Correia, Márcio W. Paixão
A versatile
and robust photocatalytic methodology to install the
amide functional group into azomethine imine ions is described. This
protocol is distinguished by its broad scope and mild reaction conditions,
which are well suited for the preparation of structurally complex
compounds in the form of amino acids, peptides, and small drug-like
molecules. Moreover, the generated pyrazolidinone core could be easily
converted into β-alanine analogues.