posted on 2024-01-22, 13:46authored byAyano Kobayashi, Yohei Saito, Katsunori Miyake, Shuichi Fukuyoshi, David J. Newman, Barry R. O’Keefe, Kuo-Hsiung Lee, Kyoko Nakagawa-Goto
Four
cytotoxic heptacyclic caged-xanthones [gambogefic acids B–E
(1–4)], a cytotoxic hexacyclic caged-xanthone
[garcilatelic acid (5)], and four biphenyl derivatives
[garcilatelibiphenyls A–D (6–9)] were newly isolated in a phytochemical study of a 50% MeOH/CH2Cl2 extract of Garcinia lateriflora (Clusiaceae). The isolated compounds were evaluated for antiproliferative
activity against five human tumor cell lines including a vincristine-resistant
line. The new caged-xanthones displayed potent activity with IC50 values from 0.5 to 6.7 μM against all tested tumor
cell lines.