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Ca2+ addition already protects against mild αSyn toxicity during exponential growth.

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posted on 2021-11-15, 18:44 authored by Lukas Habernig, Filomena Broeskamp, Andreas Aufschnaiter, Jutta Diessl, Carlotta Peselj, Elisabeth Urbauer, Tobias Eisenberg, Ana de Ory, Sabrina Büttner

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    PLOS Genetics

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    triggers premature cellulariron remain unchangeddiv >< pdependent lysosomal proteolysisconsequence restores survivalcellular proteostasis networkboosts lysosomal proteolysisreduces αsyn oligomerizationlysosomal protease cathepsindependent phosphatase calcineurinadjusts intracellular ca2 +protein critically linkedadministration prevents ααsyn ),human αcritically dependsstimulating calcineurinstimulates cathepsinparkinson ’organismal deathneurotoxic proteinsneuroprotective rolemolecular interplayhomeostasis resultsheterologous expressionexternal administrationdrosophila modelsdisrupted ca

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