posted on 2021-02-01, 17:03authored byHarshvardhan Singh, Chiranjit Sen, Eringathodi Suresh, Asit B. Panda, Subhash C. Ghosh
An
atom-economical and efficient route for the direct amidation
and amination of aryl C–H bonds using our synthesized recyclable
heterogeneous Cu-MnO catalyst is reported here. The direct C–H
amidation was carried out using a simple amide without any preactivated
coupling partner, and simple air was used as the sole oxidant. The
reaction proceeds very smoothly with a broad range of substrates containing
numerous functional groups in very good to excellent yields. Direct
C–H aminations with a secondary amine were carried out under
base-, ligand-, and external oxidant-free conditions in very good
to excellent yields in very mild conditions. Both the amidation and
amination can be scaled up on a gram scale with similar yields. The
major advantage is that our catalyst is recyclable and reused several
times without any significant loss of reactivity.