COVID GLOSSARY

In Service Of The Combatant Health Service Community : In Brief

Dr Jagadish Behera, MBBS, MD,

Diabetologist, Geriatrician and Preventive Cardiologist

Plot 15, Aryavarta, Road No 12, Jagannath Nagar, Rasulgarh, Bhubaneswar, Odisha, India, 751025.

E mail - drbaibhav.81@gmail.com

Deepak Bhattacharya, Ph.D.

Drug Discovery, QC & Fight Cancer At Home;

C/o Sri Radha Krishna Raas Mandir

Kedar Gouri Road, Bhubaneswar-India, 751002. e.mail : oddisilab1@dataone.in

COVID-19 : (co-vi-d) corona virus disease. SARS-CoV-2 : severe acute respiratory syndrome – Corona virus sub species-2 {1}. It is a RnA particle : Ribo-nucleic Acid (the whole virus is a RNA (means the nuclease-insider of the inner- is acid in fluttering ribbon form). Particle (virus) : the CoV-2 virus is a particle i.e., its size is 1x10-9 = nano meter in cross section/diameter (1meter ÷ 100,0000000 = a nano meter). CoV-2 virion (single virus) is a nano member (40-80nano meters). It is a particle. Symptoms : that what is visible & felt by the patient and the clinician at point of examination. In case of covid the symptoms are :~ fever be 37.5°C (99-1000 F; i.e. low pyrexia); acute Lymphocytopenia (< 1500 cells mm3); cum Leukopenia; mild Thrombocytopenia (< 150,000 mm3); Rhabdomyolysis; bilateral Fibrosis i.e., patchy shadowing (ground glass type) with prominent heavy-stringy exudates (mucus). WBC distribution width; high C-Reactive protein; Chloride ion deficiency; etc. Pneumonia; Pulmonary crisis; acutely down-turned thoracic cage mechanics; Right ventricle failure; acute heart failure; acute kidney failure; i.e., a cascade is the reported order {2}.

Symptoms NOT noted :~ No damage to the underlying pulmonary matrix as are noted in Tuberculosis; etc., (not noted even in end stage or post mortem covid ). Other less notable symptoms being WBC distribution width; high C-Reactive protein; Chloride ion deficiency; etc.,{3}.

Contagion : an infection or disease that spreads very efficiently via physical contact or even mere closeness. Pandemic : an disease that has spread swiftly encompassing a vast geographic area and or sub-population. Infectious : an disease or malady that afflicts a being (living body) by entering in. Diagnosis : assessment and judgement on the disease/malady and its related issues via naked eye. Touch, feel, smell, and or via using tools, implements, software, systems and equipments and machines. Prognosis : the future of the malady and or that what is going to happen to the afflicted being. Prescription : opposite of proscribe (banned); must take; permitted to take solely.

Pyrexia : Fever, normally high fever ( in case of covid fever is very low !).

Lymphocytopenia : Lymphocytes are the most vital group of white blood cells WBC; they rush to disease spots and fight on behalf of the body; each fights numerously, variously and fights many one after another and keep us fit. 1 lymphocyte can kill many. Such action is known as phagocitisation. Lymphocytopenia means the lymphocytes have been killed ! AND or are no more in production (dangerous proposition indeed)... suggests bone marrow suppression and or destruction inside the lungs of the covid patient.

Leukopenia : Apart lymphocyte there are many an other WBCs (which normally one gets tested in day-to-day CBC/DC count reports). All together are known as Leucocytes. In covid all such WBC are also noted in down turned state. Suggests entire defence mechanism to be in knocked down.

Thrombocytopenia : Thrombocytes stop flood from flowing out in an unending manner. They form plaques and stop any bleeding point on the body. In covid thrombocytes are destroyed and spontaneous bleeding internal or external becomes imminent. Super danger indeed.

Rhabdomyolysis : severe - acute muscle wasting. Particularly the large working musculatures. Severe means continuous. Acute means at any point of time/instant. Covid draws upon protein and even possibly other constituents of the musculature (to form the fibrosis) which is why muscle wasting (scouring) with unbearable cessation less shooting pain. Note : may also be due response pathology ? Large functional muscles are loaded with fibbers. Any strange (inter organ-intra location mobilisation) ??

Fibrosis : Formation of fibbers normally inside the body at any place where fiber is not genereated and if generated causes severe & acute problems e.g., covid – lungs. In covid under X-ray image the lungs both side exhibit diffused fibrosis clinically termed as ‘ground glass like effect’.

C-Reactive protein : it is an indication of some deep seated malady/systemic disease.

Chloride ion deficiency : from diagnostic point and more specially from bio-physics & patho-physiology means sodium (Na) salt is not being used only the chloride ion is being selective consumed without adequate replenishment + bio-synthesis failure (danger).

Pneumonia : Fatty degeneration of the lungs. Stringy mucus (also) Unable to exchange air. With or without fluid. Fatal.

Pleurisy : The lungs (either side lobes) have 2 layers of thin tough very flexible yet dexterous membrane that do not permit gas pass. Assists in pump back. Due covid it gets filled with stringy mucous; fluid and looses its parent properties.

Pulmonary crisis : Break of the smooth cycle of breathing; long; slow and with hard effort put-in sound. Pre to End of life stage.

Acutely down-turned thoracic cage mechanics : Chest cage is no more expanding nor contracting. End of life stage.

Right ventricle failure : Lungs no more sending adequate quantity of blood into the right side of the heart. Heart running dry. Valves & heart muscle of the right side getting damage.

Acute heart failure : As corollary to ventricle failure the whole heart fails to work in its previous symphonic cadence = failure.

Acute kidney failure : In covid because the diseased-fibrotic lungs is no more able to exchange oxygen there is steady rise in large number of myriads forms of particulates andcell debries and even particles (which all would have otherwise got oxidised and or carbonated or phosphorylated...etc.); many other organs such as the very vital pancreases also starts malfunctioning due to low oxygen and or altered level of other blood gases and ketons (versatile & dynamic chemical reaction starting members). Kidney function initially alters. Then gets chocked. Finally fails.

These clinico-bio physical parameters aberrations & deviations are based on common maximum (mostly China reports). May change over time. Moreover, individual cases may vary due to co-morbidities. Fatality is more related to geriatric; catabolic; COPD; cardio-thoracic; nephritic etc., pre existing morbidities.

CONCLUSION :

Too early to draw. Covid in simple engineering terms = constriction of the lungs by internal systemic swift growth (much alike) of fibrosis resulting in structural alteration becausing a mechanical dis-function, failure and demise happens due flooding of the lungs (feeling of death by sinking) – as response pathology. Albeit even kidney failure; and many a other symptoms viz : Leukopenia \lymphocytopenia et.al., are in our considered view ‘Response Pathologies’. Swiftly knocking down the virus posits as the panacea. We do not propose any revisionist theory. We are open to correction & editing/s.

REF :

1 - ICTV - International Committee on Taxonomy of Viruses, 11-02-2020, London, UK.

2 – NIH-USA-Figshare.

3 - Bhattacharya & Behera, 2020. IJONS, Vol.10 (59). in press.

Author 1 :

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Author – 2 : (for more about COVID & AVIR & anti virus indo indigenous native works)

Has been associated with virus drug discovery since 2000.

Had participated with NCCAM-NIH-USA , with MOU.