CD11C antigen presenting cells with high B7-H4 expression in active tuberculosis patients are associated with low stimulatory capacity to T cell proliferation.
posted on 2016-06-13, 00:00authored byWD Wang, GB Liu, JA Zhang, YB Lu, YC Gao, YC Dai, SY Yu, Y Jia, XX Fu, Z Chen, F Qiu, LL Yi, ZW Chen, J Zhong, JF Xu
B7-H4 is a co-inhibitory molecule that negatively regulates T lymphocytes, playing a role in immune suppression
many disorders. However, the role of antigen presenting cells (APCs)-expressing B7-H4 in active pulmonary
tuberculosis (ATB) remains poorly understood. Here, we demonstrated that B7-H4 expression on CD11c APCs increased
in patients with ATB. B7-H4 expression on CD11c APCs was associated with high expression of HLA-DR and
CD86 both in healthy controls (HCs) and in ATB patients. However, CD86 expression in B7-H4-expressing CD11c
APCs was significantly lower in ATB patients compared to that in HCs. Importantly, B7-H4 expressing CD11c APCs
from ATB patients showed a lower stimulatory capacity to T cell proliferation than those from HCs in mixed leukocyte
culture test. Collectively, our data suggest that the evaluation of B7-H4 expression in CD11c APCs in patients with
active tuberculosis might be one of the key molecular mechanisms for the dysfunction of APCs in TB patients. B7-H4
may have important implications in the prevention and treatment of patients with ATB.
Funding
This work
was supported by the National Natural Science
Foundation of China (81273237, 81570009),
Natural Science Foundation of Guangdong
Province (2015A030313513), the Key Project
of Science and Technology Innovation of
Education Department of Guangdong Province
(2012KJCX0059), the Science and Technology
Project of Dongguan (2012105102016,
2014108101018) and the Science and Technology Innovation Fund of Guangdong Medical
College (STIF201110, B2012078).