pgen.1011159.s006.pdf (1.72 MB)
Bidirectional transcription at TRPS1 peaks increases upon TRPS1 depletion.
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posted on 2024-02-20, 18:35 authored by Thomas G. Scott, Kizhakke Mattada Sathyan, Daniel Gioeli, Michael J. GuertinMA plot of TRPS1 ChIP-seq peaks from Fig 3G, with fold change values representing bidirectional transcription in the 30 minute dTAG-13 and dTAGV -1 at 50nM each (dTAG) treatment condition relative to the DMSO condition. Testing for a TRPS1 cistrome-wide increase in bidirectional transcription, the ANOVA F-test p-value was < 2.2*10-16.
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inducible degron tagcommon genetic variantsbreast cancer riskfamily transcription factorer redistribution leadshigh trps1 activityrelated gene setsdiv >< ptrps1 regulates transcriptioner target genesrepressing transcriptiontrps1 modulatestrps1 primary trps1taken togetherrepressive gataregulated genesprimary effectsparticularly sensitiveinducing degradationgenomic distributiongenes relatedestrogen signalingdirect targetsdata suggestcalculated usingacutely deplete80 percent
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