posted on 2021-12-09, 14:36authored byLin Liu, Fang-Fang Duan, Ying Gao, Xiao-Gang Peng, Jin-Ling Chang, Juan Chen, Han-Li Ruan
Aspersteroid
A (1), a highly rearranged 1(10 →
6)-abeo-18,22-cyclosterol, together with two new
18,22-cyclosterols (2 and 3), was isolated
from the culture extract of Aspergillus ustus NRRL
275. Their structures were determined by spectroscopic analysis, X-ray
diffraction, modified Mosher’s method, and Rh2(OCOCF3)4-induced electronic circular dichroism experiments.
Compound 1 represents a new carbon skeleton with an uncommon
6/6/6/5/5 ring system, which is presumably biosynthesized from A-ring
scission, double 1,2-shifts, and C-18/C-22 cyclization. Compound 1 exhibited potent immunosuppressive and antimicrobial activities.