posted on 2021-10-20, 22:17authored byZhen-Yu Wang, Biao Ma, Hui Xu, Xing Wang, Xu Zhang, Hui-Xiong Dai
Herein, we report the arylation,
alkylation, and alkenylation of
aryl ketones via a palladium-catalyzed Suzuki–Miyaura cross-coupling
reaction. The use of the pyridine-oxazoline ligand is the key to the
cleavage of the unstrained C–C bond. The late-stage arylation
of aryl ketones derived from drugs and natural products demonstrated
the synthetic utility of this protocol.