Antiviral activities of GK2 against WT HCMV and mutant HCMV C214S.

Chen, Han; Lye, Ming F.; Gorgulla, Christoph; Ficarro, Scott B.; Cuny, Gregory D.; Scott, David A.; Wu, Fan; Rothlauf, Paul W.; Wang, Xiaoou; Fernandez, Rosio; Pesola, Jean M.; Draga, Sorin; Marto, Jarrod A.; Hogle, James M.; Arthanari, Haribabu; Coen, Donald M.

doi:10.1371/journal.ppat.1011781.s005

ppat.1011781.s005.pdf (506.37 kB)

Antiviral activities of GK2 against WT HCMV and mutant HCMV C214S.

journal contribution

posted on 2023-11-17, 18:41 authored by Han Chen, Ming F. Lye, Christoph Gorgulla, Scott B. Ficarro, Gregory D. Cuny, David A. Scott, Fan Wu, Paul W. Rothlauf, Xiaoou Wang, Rosio Fernandez, Jean M. Pesola, Sorin Draga, Jarrod A. Marto, James M. Hogle, Haribabu Arthanari, Donald M. Coen

HFF cells infected with each virus indicated were incubated with GK2 at different concentrations. Automated plaque reduction assays were performed at 6 dpi. Cytotoxicity assays of GK2 were performed in parallel. Error bars represent standard deviations from three independent experiments. Where no error bars are seen, the standard deviations were too small to be visible. Curves were fit using nonlinear regression and ED₅₀ values and the 95% confidence intervals (CI) and p value for the difference between the ED₅₀’s were calculated using GraphPad Prism 9.5.1 for MacOS.

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