posted on 2024-02-28, 14:39authored byHee-Kyeong Kim, Su-Ji Han, Young-Sam Cho, Hyun-Ha Park
Staphylococcus aureus (S. aureus) is a common bacterium that can cause a
wide range of infections in humans. The growth of these bacteria is
inhibited by strategies using antibiotics and/or nanomaterials. However,
nanomaterials and antibiotics can cause cytotoxicity and antibiotic
resistance. Recent research has focused on achieving mechanical inhibition
of bacterial growth through the surface nanostructure. Antibacterial
use of nanostructured surfaces does not need antibiotics. Meanwhile,
transparent films are necessary in the medical, optical, and automotive
industries. In this study, we proposed a flexible, transparent, antibacterial,
and antifogging film with a nanostructured surface. The bactericidal
and bacteriostatic effects were observed on the arrayed nanopillars
according to spacing. For S. aureus, bactericidal effect was observed at a nanopillar spacing of 300
nm, and bacteriostatic effect was observed at 500–1000 nm.
Furthermore, the antibacterial rate was improved by 94.9% through
MPC polymer coating at the surface. In addition, the MPC coating maintained
an antibacterial rate of 86.6 and 64.1% for 7 and 14 days, respectively.
The hydrophilic MPC-coated surface has properties of antifogging and
transparency for potential usage in optical devices. This study provides
insight into the potential of nanostructured surfaces using a dual
strategy to prevent bacterial infections.