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Anti-Shine-Dalgarno mutations and sub-inhibitory concentration of chloramphenicol boost succinate utilisation.
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posted on 2024-03-08, 18:39 authored by Nicolas Wenner, Xiaojun Zhu, Will P. M. Rowe, Kristian Händler, Jay C. D. HintonAnti-Shine-Dalgarno mutations and sub-inhibitory concentration of chloramphenicol boost succinate utilisation.
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small regulatory rnalong lag phaseexperimental evolution approachdiv >< pdiscoveries shed lightredundant regulatory systemsmultiple regulatory systemsslow growth ratesigma factor rposcentral carbon metabolismenteric bacteria exhibitsalmonella enterica inhibit succinate utilisationbacterial succinate utilisationsole carbon sourcegrowth inhibition phenomenonindependent systemssalmonella succinate utilisationrpos regulationcomplete rposspecific utilisationwithin macrophagesvitro tightly regulatepoorly understoodpathogenic bacteriumnovel mechanismmammalian gutisolate fasthigh levelsgrowing mutantsgenetic basis
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