Anodic C(sp3)–H Acyloxylation of
Indolin-3-ones Enabled by Oxidant-Free Cross-Dehydrogenative C(sp3)–O Coupling

Zou, Canlin; Wu, Hongting; He, Jiangtao; Hu, Yunfei; Deng, Weijie; Li, Xinling; Hu, Jinhui; Li, Yibiao; Huang, Yubing

doi:10.1021/acs.joc.1c02644.s001

jo1c02644_si_001.pdf (5.82 MB)

Anodic C(sp³)–H Acyloxylation of Indolin-3-ones Enabled by Oxidant-Free Cross-Dehydrogenative C(sp³)–O Coupling

journal contribution

posted on 2022-01-05, 17:06 authored by Canlin Zou, Hongting Wu, Jiangtao He, Yunfei Hu, Weijie Deng, Xinling Li, Jinhui Hu, Yibiao Li, Yubing Huang

An efficient anodic C(sp³)–H acyloxylation protocol has been established via intermolecular cross-dehydrogenative C(sp³)–O coupling. The protocol provides various C2-acyloxy indolin-3-ones without the addition of metal catalysts and external oxidants because indolin-3-ones can be directly oxidized at the anode. The effective application of several medical drugs and the realization of the gram-scale experiment have proven the practicality of this protocol.