posted on 2022-01-28, 14:35authored byXian-Zhang Liao, Man Liu, Lin Dong
An effective strategy for the synthesis
of vinylidenequinazolines
has been efficaciously developed, which involves Rh(III)-assisted
C–H amidation followed by ring-opening and intramolecular annulation.
This protocol shows a straightforward way to construct diverse quinazoline
units with a wide functional group compatibility from readily available
isoxazoles and dioxazolones.