pgen.1009385.s013.pdf (93.44 kB)
Allele frequencies in the drive populations at generation 25.
journal contribution
posted on 2021-02-18, 19:53 authored by Georg Oberhofer, Tobin Ivy, Bruce A. HayWe measured allele frequencies of the drive elements by outcrossing 100 males from the different drive replicates at generation 25 to w1118 virgins and scored the offspring for their respective markers. C = Cleaver (Cas9, 3xP3-td-tomato), R = Rescuetko (Rescue, opie-tomato), + = WT. Examples of how scoring was performed are in S1 Data (allele frequencies).
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recoded versiongene drive Gene drive elementsDNA sequence-modifying enzymedrive strengthrecombination frequencyLOF allelesCas 9-dependent mannertrait spreadnovel pointCas 9drive mechanismsSelf-sustaining Cleaveobservations showsplit ClvRLOF allele creationfuture driveCargoCas 9 transiently experiences driveCas 9 decreasesuse modelingRescuelinkage disequilibriumCas 9 frequency
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