Alkylation of 6-thiopurine derivatives by the Mitsunobu reaction

do Espírito Santo, Rafael Dias; da Silva, Bianca Nascimento Monteiro; Rabi, Jaime A.; Pinho, Vagner D.

doi:10.6084/m9.figshare.21804944.v1

lncn_a_2163501_sm9204.docx (21.47 MB)

Alkylation of 6-thiopurine derivatives by the Mitsunobu reaction

journal contribution

posted on 2023-01-03, 06:00 authored by Rafael Dias do Espírito Santo, Bianca Nascimento Monteiro da Silva, Jaime A. Rabi, Vagner D. Pinho

Alkylation of thiopurine derivatives with alcohols by the Mitsunobu reaction are reported in moderated to good yields. The method was applied in synthesis of number of thiopurine and thiopurine ribosides derivatives.

Funding

This work was supported by the by the Brazilian National Research Council (CNPq), under grant (403543/2020-7) and the Brazilian Company of Research and Industrial Innovation (EMBRAPII, under grant 015/2020).

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Thiopurines thiopurines riboside Mitsunobu reaction

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Alkylation of 6-thiopurine derivatives by the Mitsunobu reaction

Funding

This work was supported by the by the Brazilian National Research Council (CNPq), under grant (403543/2020-7) and the Brazilian Company of Research and Industrial Innovation (EMBRAPII, under grant 015/2020).

History

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