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Aggregation-Induced Emission (AIE), Life and Health

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posted on 2023-11-17, 04:02 authored by Haoran Wang, Qiyao Li, Parvej Alam, Haotian Bai, Vandana Bhalla, Martin R Bryce, Mingyue Cao, Chao Chen, Sijie Chen, Xirui Chen, Yuncong Chen, Zhijun Chen, Dongfeng Dang, Dan Ding, Siyang DingSiyang Ding, Yanhong Duo, Meng Gao, Wei He, Xuewen He, Xuechuan Hong, Yuning HongYuning Hong, Jing-Jing Hu, Rong Hu, Xiaolin Huang, Tony D James, Xingyu Jiang, Gen-Ichi Konishi, Ryan TK Kwok, Jacky WY Lam, Chunbin Li, Haidong Li, Kai Li, Nan Li, Wei-Jian Li, Ying Li, Xing-Jie Liang, Yongye Liang, Bin Liu, Guozhen Liu, Xingang Liu, Xiaoding Lou, Xin-Yue Lou, Liang Luo, Paul R McGonigal, Zong-Wan Mao, Guangle Niu, Tze Cin OwyongTze Cin Owyong, Andrea Pucci, Jun Qian, Anjun Qin, Zijie Qiu, Andrey L Rogach, Bo Situ, Kazuo Tanaka, Youhong Tang, Bingnan Wang, Dong Wang, Jianguo Wang, Wei Wang, Wen-Xiong Wang, Wen-Jin Wang, Xinyuan Wang, Yi-Feng Wang, Shuizhu Wu, Yifan Wu, Yonghua Xiong, Ruohan Xu, Chenxu Yan, Saisai Yan, Hai-Bo Yang, Lin-Lin Yang, Mingwang Yang, Ying-Wei Yang, Juyoung Yoon, Shuang-Quan Zang, Jiangjiang Zhang, Pengfei Zhang, Tianfu Zhang, Xin Zhang, Na Zhao, Zheng Zhao, Jie Zheng, Lei Zheng, Zheng Zheng, Ming-Qiang Zhu, Wei-Hong Zhu, Hang Zou, Ben Zhong Tang
Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents and imaging techniques currently being used to assess health and treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) has shown great potential in biological applications due to its advantages in terms of brightness, biocompatibility, photostability, and positive correlation with concentration. This review provides a comprehensive summary of AIE luminogens applied in imaging of biological structure and dynamic physiological processes, disease diagnosis and treatment, and detection and monitoring of specific analytes, followed by representative works. Discussions on critical issues and perspectives on future directions are also included. This review aims to stimulate the interest of researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting the development of AIE in the fields of life and health.

Funding

The authors are grateful for the funding support from the National Natural Science Foundation of China (21788102, 21877021, 32160661, 52003228), the Research Grants Council of Hong Kong (C6014-20W), the Innovation and Technology Commission (ITC-CNERC14SC01), Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ2021324134613038, GJHZ20210705141810031), Shenzhen Key Laboratory of Functional Aggregate Materials (ZDSYS20211021111400001), the Open Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou 510640, China (2019B030301003), the Project funded by China Postdoctoral Science Foundation (2022M72308), the National Natural Science Foundation of China (62105184), the National Natural Science Foundation of China (Grant no. 21871108), NSF-2107619, Faculty Summer Fellowship from The University of Akron, the National Natural Science Foundation of China (32172296), and Japan Society for the Promotion of Science (the MEXT/JSPS KAKENHI grants 23H02036 and 17H05145).

History

Publication Date

2023-08-08

Journal

ACS Nano

Volume

17

Issue

15

Pagination

59p. (p. 14347-14405)

Publisher

American Chemical Society

ISSN

1936-0851

Rights Statement

© 2023 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0: (https://creativecommons.org/licenses/by/4.0/)

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    Keywords

    aggregation-induced emissionbioimagingbiomedical applicationcombined therapydetectionluminescent materialmonitoringphototheranosticsprecision medicine

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    CC BY 4.0

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