pone.0297803.s001.docx (84 kB)
Agarose gel electrophoresis of GAG extract from marine snail Rapana venosa before incubation with heparinase III (Hep III) and chondroitinase ABC (Chase ABC).
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posted on 2024-02-15, 18:42 authored by Alexandra Gaspar-Pintiliescu, Laura M. Stefan, Elena Mihai, Catalina Sanda, Vasile S. Manoiu, Daniela Berger, Oana CraciunescuStandards of bovine condroitin sulfate (CS) and heparan sulfate (HS) migrated in similar conditions. 1 –CS; 2 –HS; 3 –GAG; 4—no sample; 5 –CS; 6 –HS; 7,8,9,10—no sample.
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novel bioactive compoundinhibit cell proliferationimportant pharmacological applicationsfree radical scavengingfourier transform infrareddiv >< pdead assays showedagarose gel electrophoresis2 cell culturestumoral cell migrationheparinase iii indicatedrapana venosa bovine heparan sulfatehigh antioxidant activityvenosa heparan sulfatespectra indicatedantioxidant activityvitro sulfate contentr extract migrationchondroitin sulfateunique moleculessulfation ratiospecific digestionslightly decreasedscarce informationpotential usemarine snailmarine glycosaminoglycansmain componenthuman hepenzymatic treatmentenzymatic digestionelemental compositiondifferent invertebratescytocompatible concentrationschondroitinase abccapacity decreasedbiomedical useantiproliferative propertiesantiproliferative effectantiproliferative activitiesalso inhibited
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