13024_2021_441_MOESM5_ESM.pdf (24.57 MB)
Additional file 5 of Preclinical modeling of chronic inhibition of the Parkinson’s disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo
journal contribution
posted on 2021-03-20, 04:42 authored by Jillian H. Kluss, Melissa Conti Mazza, Yan Li, Claudia Manzoni, Patrick A. Lewis, Mark R. Cookson, Adamantios MamaisAdditional file 5:.
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Michael J. Fox Foundation for Parkinson's Research National Institute on Aging (NIA)
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kinase inhibitionLRRK 2 autophosphorylationProteomic analysisprotein kinaseLRRK 2 inhibitiontrafficking pathwaysLRRK 2kinase LRRK 2kinase 2 genewashout conditionsLRRK 2 inhibitorpS 106 Rab 12brain tissuevivo PD modelendolysosomal systemRab substrates10 weeksin-diet administrationPreclinical modelingvivo AbstractRab GTPases phosphorylationLRRK 2 activityPD patientsproteomic analysesmitochondrial proteinspharmacodynamic responseMLi -2G 2019S LRRK 2 knock-in miceMLi -2 treatment
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