Additional file 5: of Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities

Garrett, Matthew; Sperry, Jantzen; Braas, Daniel; Yan, Weihong; Le, Thuc; Mottahedeh, Jack; Ludwig, Kirsten; Eskin, Ascia; Qin, Yue; Levy, Rachelle; Breunig, Joshua; Pajonk, Frank; Graeber, Thomas; Radu, Caius; Christofk, Heather; Prins, Robert; Lai, Albert; Liau, Linda; Coppola, Giovanni; Kornblum, Harley

doi:10.6084/m9.figshare.6158681.v1

40170_2018_177_MOESM5_ESM.pdf (19.6 kB)

Additional file 5: of Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities

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posted on 2018-04-17, 05:00 authored by Matthew Garrett, Jantzen Sperry, Daniel Braas, Weihong Yan, Thuc Le, Jack Mottahedeh, Kirsten Ludwig, Ascia Eskin, Yue Qin, Rachelle Levy, Joshua Breunig, Frank Pajonk, Thomas Graeber, Caius Radu, Heather Christofk, Robert Prins, Albert Lai, Linda Liau, Giovanni Coppola, Harley Kornblum

IDH wildtype cells show faster growth rate compared to IDH1 mutant cells. Six IDH wildtype and five IDH1 mutant gliomasphere cultures were assessed for proliferation rate by flow cytometry using carboxyfluorescein succinimidyl ester (CFSE). (pâ<â0.05). (PDF 19Â kb)

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2-hydroxyglutarate Metabolism Nucleotide Radiation Glioma

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Additional file 5: of Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities

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National Institutes of Health

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